• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    New compounds having the following formula I, (FORMULA) wherein R<s1>s is hydrogen or methyl R<s3>s is hydrogen, methyl, hydroxymethyl, carboxyl, alcoxycarbonyl having 2 to 5 carbon atoms, carbamoyl or cyano and R<s2>s is one of the groups a) to i); these groups are: (FORMULA) and may be used as medicines. These compounds have antiarrhytmic //c-adrenergic blocking and antihypertension properties; and in case of compounds carrying in position 2 of the indole cycle a cyano or carbamoyl group, ss-adrenergic blocking properties. These compounds are obtained by amination.
    公开号:SU826954A3
    申请号:SU792784399
    申请日:1979-07-02
    公开日:1981-04-30
    发明作者:Бертольд Рихард
    申请人:Сандос Аг (Фирма)；
    IPC主号:
    专利说明:

    (54) A METHOD FOR OBTAINING INDOLA DERIVATIVES i), - R, Rm where Ri together with Rn represents compos-o-phenylene, when RJ is a cyano group, E together with Rt, is o-phenylene or lower alkylene, in which the nitrogen atom bound to R is separated from the nitrogen atom bound to Rn f by two or three carbon atoms, Rm is a hydrogen volume or alkyl is 1-4C with the proviso that when R is a hydrogen atom, and 2 is group b), R is carbamoyl or cyano, and when Rg is group h), K represents a hydrogen atom. The method consists in the interaction of compounds of the general formula (1) L) where R and R have the above values, and RX is a group of the formula -CH-CH or CH (OH) CH2Y, where y is chlorine, bromine OR 4 R4-S02.0 where is tolyl or lower alkyl with a compound of the general formula where 2 is as defined above. The reaction is preferably carried out in isopropanol or in a suitable ester, for example dioxane. It is also possible to use an excess of an amine as a solvent. Another way is to carry out the reaction in the melt of a mixture of reagents. The reaction temperature may range from about 20 to about 200 ° C; comfortable is the tempo. Boiling point under reflux (when using a solvent). Free bases of the compounds can be converted to salts using known methods and n-turn. Suitable acids suitable for the formation of acid addition salts are, in particular, maleic, malonic, and fumaric. In the proposed compounds, the hydrogen atoms, for example, in the 2-position and the 3-aminopropoxy side chain may be asymmetrically substituted, as a result of which these compounds may exist. either in the form of a racemate or in a separate optical isomer. Preferred is an isomer having the S-configuration of said asymmetrically substituted carbon atom in the 3-amino propoxy side chain. Individual optical isomers can be obtained, for example, using optically active starting materials, or as a result of fractional crystallization using optically active acids. The compounds thus obtained have a high biological activity and are a valuable supplement to the already existing drugs used in medicine. Example 1. 4- {3- 4- (1,2-dihydro-2-oxobenzimidazol-4-yl) -piperidin-1-yl -2-hydroxypropoxy 3 -1H-indole-2-carbonitrile. A mixture consisting of 10 g of 4- (2,3-epoxypropoxy) -1H-indole-2-carbonitrile and 10, 18 g of 1- {4-piperidinyl-) -benzimidazol-2 (3N) -one in 150 ml of dioxane The mixture is heated under reflux for 20 hours, then the reaction mixture is cooled, treated with activated carbon and filtered. The solution is concentrated and crystallized by adding ethanol to it (i.e. the compound indicated in the title is 228-230 ° C after recrystallization from tetrahydrofuran-methylene chloride; mp. The acid malonate of the said compound is 199 ° C (with decomposition)). Yield 81%. The original product is obtained in the following way. 7.0 g of 4- {2,3-epoxypropoxy) -1H-indole-2-carboxamide, 90 ml of dioxane and 7.2 g of pyridine are cooled with stirring, 10.45 g of trifluoroacetic anhydride are dissolved separately in 45 ml of dioxane and slowly adding to the reaction mixture while maintaining the temperature at 10-12 seconds. After 2 hours, during which the reaction mixture is stirred at room temperature, 50 ml of methylene chloride are added to the mixture, the mixture is stirred and decanted twice with 300 ml of water, after which the separated organic layer is dried over magnesium sulfate. The purple solution is filtered through talc and the solvent is distilled off. The viscous residue is chromatographed on 200 g of silica gel (Merck No. 7733) using methylene chloride containing 1% methanol as eluent. The purified fractions were dissolved in a mixture of methanol and methylene chloride, the resulting solution was concentrated and ether was added to it. The crystals thus formed are filtered off and washed with ether and dried in vacuo at 60 ° C (T.P.L49-151 ° C). From the corresponding compounds corresponding to the general formula I, for which Rj (is a -CH-CH2 group, the compounds described in the table and corresponding to the general formula T can be obtained by reacting with the corresponding compounds of the general formula III according to The method described in Example 1, Example 31, 2-dihydro-2-oxabenzimidazol-1-yl) -peed reedin-yl 3 -2-hydroxypropoxy 1-1Ntindole-2-carbonitrile. Analogously to example 1, out of 5 g of 4- (3-chloro-2-hydroxypropoxy-1H-indole-2-carbonitrile, the desired product is obtained; mp. Malonic acid 199 ° C (decomposed), yield 76%. Example 32. -4 -fl, 2-dihydro-2-oxobenzimidazol-1-yl) -piperidin-1-yl} -2-hydroxypropoxy -1H -indole-2-carbonitrile. In analogous example 1, starting from 6 g of 4- (3-bromo -2-hydroxypropoxy) -1H7 -indole-2-carbonitrile, get c "left product, so pl. sour malonite 199S (raelozh), yield 79%. Example 33.4- {3-C4- (1,2-dihydro-2-oxobenzimidazol-1-yl) -piperidin-1-yl -2-oxypropoxy) -1H-indole-2-carbonitrile. The expected product is obtained analogously to example 1 of 6 g of 4- (2-hydroxy-3-mesyloxypropoxy) -1H-indole-2-carbonitrile. M.p. sour malonate (decomposed) - yield 74%. Example 34. (1,2-Dihydro-2-oxobenzimidazol-1-yl) -piperidin-1-yl 1 -2-hydroxypropoxy -1 H-indole-2 carbonitrile. . Analogously to example 1, a target product is obtained from 7 g (4- (2-hydroxy-3-T1-tosyloxy) 6-oxo-1H-indole-2-carbonitrile. Mp. Malonic acid 199 ° G (disloyal), 70% yield. Example 35.4- {g-G4- (1,2-dihydro-2-oxobenzylimidazol-17Il) -piperidin-1-yl.) - 2-hydroxypropoxy J-1H-in dol-2-carbonitrile. Analogously to Example 1, the target product is obtained from 7 g of 4- {2-hydroxy-3- - 1-tosyloxypropoxy) -1H-indole-2-carbonitrile. M.p. acid malonate 199 ° C (decomposed), yield 70%.
    COOEt Me H CONHj Group b) 8
    CONH,
    78
    201-203 145-146 107-109 fu 231-233 ch 170-172 fu 204-206 178-180
    irZ IZIiniZI IZ3 ITIZI n Z I CN-N V-N NP continuation table
     ASYLETS r- A 191192
    CH OH
    29
     ten
    626954
    Table continuation
    71
    124-126
    CH OH
    30 Note
    权利要求:
    Claims (1)
    [1]
    Invention Formula
    The method of producing indole derivatives of the general formula: where R is hydrogen, methyl; R is hydrogen, methyl, hydroxymethyl, alkoxycarbonyl with 2-5 carbamyl, cyano group; R2 is one of the groups a) to i): KoRi-nOns,) where P is O or 1,, Rb / Rc is independently alkyl with 1 where Rg is alkyl with 1-4C - “S,. sveCD
    where IRf, is a halogen with atomic number from 9 to 35;
    81
    173-175
     h
    -ABOUT
    J, -MN-S {CH OH),
    e)
    SOUTH
    SYA-CH | ch - hydrochloride, fu - bis (basic) fumarate, nfu sour fumarate, nd - bis (basic) nftalin-1,5-disulfonate. Me is methyl, Et is ethyl, i-Pr is isopropyl. ) -VK-C-O Ki n in which R, together with R, is represented by o-phenylene, when Rj is cyano-rpynna, R; together with R is o-phenylene or lower alkylene, KOTOII separates with two or three carbon atoms a nitrogen atom bonded to R from a nitrogen atom bonded to Rn and R „is a hydrogen atom or alkyl from 1-4C with the proviso that when R is hydrogen and H, group b), K is carbamoyl or cyano, and when RZ is group h), Rj is hydrogen, differing there, that the corresponding compound corresponding to general formula 1 is reacted: where R and R3 have the indicated values, and RX is a group of the formula or CH (OH) CHjy, where y is sulfur, bromine or, where Rij is tolyl or not our alkyl with a compound of the general formula III Rj-H, where 2 has the above values in an organic solvent medium. Priority on the grounds: 03.07.78 R - hydrogen, methyl; cyano group; Ra groups a), b), c), e f), g), h); -Oggde R and Rf, together B1 yp o-phenylene or ethylene. 07/03/78 RI - hydrogen, methyl R hydrogen, methyl oxymethyl, alkoxycarbonyl with 2 carbamoyl; Rj - groups a), b), e l), g), h); r- -T where R and RO together Ri Dp o-phenylene or ethylene; with the proviso that A) if RI is hydrogen and R2 is carbamoyl; B) if R 2 is a group Vi), then R-} is hydrogen; / H - group-M VN NH, I 1. . R; Rn ones with R are o-fucked. RI is hydrogen, methyl; R-} - Cyano-group; Kr is a group of d) or Ri Lp L1 LP is hydrogen R- and R ,, along with CG. R is hydrogen, methyl; hydride, methyl; K x - tyttglg ogt lholmpm tt hydrogen, methyl, oxymethyl, alkoxycarbonyl 2-5C carbamoyl; Rj is the group d) or i о N / 1 I, RI Rl .. where R and Rf, in the glass is o-felien, aRn is alkyl, 1-4C, provided that if R is hydrogen, R2 is group b) , R3arbamoyl. Full-time information, about the attention in the examination of K. K., Pearson D. Organic. M., Mir, 1973, 1, 529.
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    同族专利:
    公开号 | 公开日
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB1129072A|1966-02-01|1968-10-02|Ici Ltd|Benzofuran and indole derivatives|
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    FR1547056A|1966-12-13|1968-11-22|Sandoz Sa|Indole derivatives and their preparation|
    US3705907A|1970-02-19|1972-12-12|Sandoz Ltd|4--3-aminopropoxy)-indole derivatives|
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    CH540253A|1971-01-07|1973-08-15|Sandoz Ag|Process for the production of new indoles|
    DE2337461A1|1973-07-24|1975-02-06|Boehringer Mannheim Gmbh|NEW INDOLDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION|
    US4076829A|1974-11-16|1978-02-28|Boehringer Mannheim Gmbh|Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases|
    DE2633839A1|1975-08-07|1977-02-24|Sandoz Ag|NEW 4-AMINOPROPOXYINDOLDE DERIVATIVES, THEIR PRODUCTION AND USE|DE2935062A1|1978-09-06|1980-03-20|Degussa|SUBSTITUTED AMINOALKYLGUANIDINE, THEIR PRODUCTION AND MEDICINAL PRODUCTS|
    DE3030047A1|1980-08-08|1982-03-11|Boehringer Mannheim Gmbh, 6800 Mannheim|NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS|
    DE3029980A1|1980-08-08|1982-03-11|Boehringer Mannheim Gmbh, 6800 Mannheim|INDOLDER DERIVATIVES AND METHOD FOR THEIR PRODUCTION|
    DE3200304A1|1981-01-16|1982-08-26|Sandoz-Patent-GmbH, 7850 Lörrach|3-AMINOPROPOXYARYL DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THEM|
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    DE3423429A1|1984-06-26|1986-01-02|Beiersdorf Ag, 2000 Hamburg|SUBSTITUTED PHENOXYALKYLAMINOPROPANOLE, METHOD FOR THE PRODUCTION AND USE THEREOF, AND PREPARATIONS CONTAINING THESE COMPOUNDS|
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    US4704390A|1986-02-13|1987-11-03|Warner-Lambert Company|Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents|
    DE3721260A1|1987-06-27|1989-01-12|Beiersdorf Ag|NEW INDOLYL PROPANOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE, AND PREPARATIONS CONTAINING THE COMPOUNDS|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    CH723578|1978-07-03|
    CH724078|1978-07-03|
    CH49179|1979-01-18|
    CH49679|1979-01-18|
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